Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 15/20 | 0.60 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10980403 | 0.88 | NOTUM (0.70) | NOTUMKEAP1CNR1EGLN2AR | |
| SCHEMBL14955603 | 0.82 | NOTUM (0.57) | NOTUMKEAP1 | |
| SCHEMBL12012868 | 0.77 | NR2E1 (0.46) | NOTUMNR2E1CNR1AR | |
| SCHEMBL10685651 | 0.75 | NOTUM (0.62) | NOTUMKEAP1EGLN2CYP1A2CYP2C9 | |
| SCHEMBL10933201 | 0.75 | NOTUM (1.00) | NOTUMKEAP1 | |
| SCHEMBL2627306 | 0.75 | NOTUM (0.55) | NOTUMKEAP1EGLN2 | |
| SCHEMBL14955543 | 0.73 | NOTUM (0.47) | NOTUMKEAP1 | |
| SCHEMBL28132535 | 0.73 | NR2E1 (0.56) | NOTUMNR2E1CNR1 | |
| SCHEMBL8739094 | 0.73 | NR2E1 (0.50) | NOTUMNR2E1CNR1ARCYP1A2 | |
| SCHEMBL10684672 | 0.73 | NOTUM (0.55) | NOTUMKEAP1CYP1A2CYP2C9CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103896865-B | 1,4-pentadiene-3-ketone compounds containing triazole amide and preparation method and application thereof | 兴义民族师范学院 | 2017-03-22 | — | — | CN | claimed |
| CN-103896865-A | 1,4-pentadiene-3-ketone compounds containing triazole amide and preparation method and application thereof | XINGYI NORMAL UNIVERSITY FOR NATIONALITIES | 2014-07-02 | — | — | CN | claimed |
| CN-103896865-B | 1,4-pentadiene-3-ketone compounds containing triazole amide and preparation method and application thereof | 兴义民族师范学院 | 2017-03-22 | — | — | CN | disclosed |
| US-20150297595-A1 | INHIBITORS OF SYK AND JAK PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. | 2015-10-22 | — | — | US | disclosed |
| EP-2323993-B1 | 2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS | PORTOLA PHARM INC (US) | 2015-06-03 | — | — | EP | disclosed |
| US-8952027-B2 | Inhibitors of syk and JAK protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| CN-103896865-A | 1,4-pentadiene-3-ketone compounds containing triazole amide and preparation method and application thereof | XINGYI NORMAL UNIVERSITY FOR NATIONALITIES | 2014-07-02 | — | — | CN | disclosed |
| US-8349860-B2 | Inhibitors of syk and JAK protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-8318755-B2 | Inhibitors of SYK and JAK protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120130073-A1 | INHIBITORS OF SYK AND JAK PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120101275-A1 | INHIBITORS OF SYK AND JAK PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-04-26 | — | — | US | disclosed |
| US-8063058-B2 | Inhibitors of syk and JAK protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063058-B2 | Inhibitors of syk and JAK protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100048567-A1 | Inhibitors of syk and JAK protein kinases | PORTOLA PHARMACEUTICALS INC. (US) | 2010-02-25 | — | — | US | disclosed |
| US-20100048567-A1 | Inhibitors of syk and JAK protein kinases | PORTOLA PHARMACEUTICALS INC. (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150297595-A1 | INHIBITORS OF SYK AND JAK PROTEIN KINASES | SYK, BTK, JAK1 | NOTUM 828/4885NR2E1 4704/4885KEAP1 3382/4885 |
| US-20120130073-A1 | INHIBITORS OF SYK AND JAK PROTEIN KINASES | SYK, BTK, JAK1 | NOTUM 828/4885NR2E1 4704/4885KEAP1 3382/4885 |
| US-20120101275-A1 | INHIBITORS OF SYK AND JAK PROTEIN KINASES | SYK, BTK, JAK1 | NOTUM 828/4885NR2E1 4704/4885KEAP1 3382/4885 |
| US-20100048567-A1 | Inhibitors of syk and JAK protein kinases | SYK, BTK, JAK1 | NOTUM 828/4885NR2E1 4704/4885KEAP1 3382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.