Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 12/20 | 1.00 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10980403 | 0.82 | NOTUM (0.70) | NOTUMKEAP1 | |
| SCHEMBL14961974 | 0.82 | NOTUM (0.75) | NOTUMKEAP1 | |
| SCHEMBL11286034 | 0.78 | NOTUM (0.64) | NOTUMEPHX2ALDH1A1KCNH2 | |
| SCHEMBL30402678 | 0.78 | NOTUM (0.64) | NOTUMEPHX2ALDH1A1KCNH2 | |
| SCHEMBL28646619 | 0.78 | NOTUM (0.63) | NOTUMKEAP1EPHX2ALDH1A1KCNH2 | |
| SCHEMBL28266369 | 0.78 | NOTUM (0.65) | NOTUMKEAP1KCNH2 | |
| SCHEMBL29471936 | 0.78 | NOTUM (0.65) | NOTUMKEAP1KCNH2 | |
| SCHEMBL21776982 | 0.77 | KEAP1 (1.00) | NOTUMKEAP1 | |
| SCHEMBL28188988 | 0.77 | NOTUM (1.00) | NOTUMEPHX2ALDH1A1 | |
| SCHEMBL10685651 | 0.77 | NOTUM (0.62) | NOTUMKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| US-4610717-A | HERBICIDES | SHELL OIL COMPANY (US) | 1986-09-09 | — | — | US | disclosed |
| US-4610717-A | HERBICIDES | SHELL OIL COMPANY (US) | 1986-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | NOTUM 1/4885KEAP1 764/4885EPHX2 2551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.