Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 6/20 | 0.64 |
| ▸ | CDK8 | P49336 | 7/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | FES | P07332 | 2/20 | 0.48 |
| ▸ | ROS1 | P08922 | 2/20 | 0.48 |
| ▸ | FER | P16591 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.48 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739293 | 0.86 | EZH2 (0.68) | EZH2L3MBTL1ATMGLA | |
| SCHEMBL8738211 | 0.86 | EZH2 (0.68) | EZH2L3MBTL1ATMGLA | |
| SCHEMBL8738307 | 0.85 | EZH2 (0.67) | EZH2L3MBTL1ATMGLA | |
| SCHEMBL8738204 | 0.85 | EZH2 (0.69) | EZH2L3MBTL1ATMGLA | |
| SCHEMBL8738629 | 0.85 | EZH2 (0.74) | EZH2L3MBTL1ATMGLA | |
| SCHEMBL8738126 | 0.85 | EZH2 (0.66) | EZH2L3MBTL1ATMGLA | |
| SCHEMBL8738621 | 0.85 | EZH2 (0.66) | EZH2L3MBTL1ATMGLA | |
| SCHEMBL8738576 | 0.84 | EZH2 (0.68) | EZH2ROCK2L3MBTL1ATMGLA | |
| SCHEMBL8739018 | 0.84 | EZH2 (0.68) | EZH2L3MBTL1ATMGLA | |
| SCHEMBL8738206 | 0.84 | EZH2 (0.73) | EZH2L3MBTL1ATMGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |