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SCHEMBL8738307

SCHEMBL8738307

Cc1ccc(-c2cccc(OCc3ccc(C(=O)NC4CC(C)(C)NC(C)(C)C4)cc3)c2)cn1

nearest known ligand 0.67

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ EZH2 Q15910 11/20 0.67
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ GLA P06280 1/20 0.45
▸ MEN1 O00255 2/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ SMPD1 P17405 1/20 0.44
▸ POLB P06746 1/20 0.43
▸ ATM Q13315 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8738621 0.90 EZH2 (0.66) EZH2L3MBTL1GLAMEN1KMT2A
SCHEMBL8738126 0.90 EZH2 (0.66) EZH2L3MBTL1GLAMEN1KMT2A
SCHEMBL8739018 0.90 EZH2 (0.68) EZH2L3MBTL1GLAMEN1KMT2A
SCHEMBL8739266 0.90 EZH2 (0.62) EZH2L3MBTL1KMT2A
SCHEMBL8738209 0.90 EZH2 (0.65) EZH2L3MBTL1GLAMEN1KMT2A
SCHEMBL8738150 0.89 EZH2 (0.64) EZH2L3MBTL1GLAMEN1KMT2A
SCHEMBL8739045 0.89 EZH2 (0.64) EZH2L3MBTL1GLAMEN1KMT2A
SCHEMBL8738211 0.89 EZH2 (0.68) EZH2L3MBTL1GLAMEN1KMT2A
SCHEMBL8738206 0.88 EZH2 (0.73) EZH2L3MBTL1GLAMEN1KMT2A
SCHEMBL8738245 0.88 EZH2 (0.65) EZH2L3MBTL1GLAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012068589-A2 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF CONSTELLATION PHARMACEUTICALS (US) 2012-05-24 — — WO disclosed