Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.34 |
| ▸ | PDE4A | P27815 | 5/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873919 | 0.86 | HTR1A (0.39) | HTR1AHTR7PDE4BPDE4APDE4C | |
| SCHEMBL874075 | 0.83 | PDE4B (0.38) | HTR1AHTR7PDE4BPDE4APDE4C | |
| SCHEMBL873918 | 0.77 | PDE4B (0.36) | HTR1AHTR7PDE4BPDE4DDPP4 | |
| SCHEMBL682752 | 0.77 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2136806 | 0.77 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL876415 | 0.73 | PDE4A (0.40) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873798 | 0.72 | PDE4A (0.40) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL878473 | 0.71 | PDE4D (0.43) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL681944 | 0.71 | PDE4D (0.43) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL874471 | 0.71 | PDE4B (0.40) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | claimed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | claimed |