Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 12/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | RAD52 | P43351 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738156 | 0.89 | EZH2 (0.76) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL2908330 | 0.89 | EZH2 (0.89) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL169747 | 0.87 | EZH2 (0.80) | EZH2MEN1KMT2AL3MBTL1PKM | |
| SCHEMBL6119822 | 0.86 | EZH2 (0.80) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL8738588 | 0.86 | EZH2 (1.00) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL6120685 | 0.85 | EZH2 (0.62) | EZH2MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL6120058 | 0.84 | EZH2 (0.67) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL6120964 | 0.83 | EZH2 (1.00) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL8738670 | 0.83 | EZH2 (0.74) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL6120593 | 0.83 | EZH2 (0.74) | EZH2MEN1KMT2AL3MBTL1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |