Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | EZH2 | Q15910 | 8/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739662 | 0.94 | MEN1 (0.60) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL8739702 | 0.90 | MEN1 (0.65) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL8739673 | 0.88 | MEN1 (0.62) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL8738911 | 0.80 | MEN1 (0.59) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL8739365 | 0.78 | MEN1 (0.57) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL6119756 | 0.76 | EZH2 (0.77) | MEN1KMT2AEZH2 | |
| SCHEMBL8738124 | 0.76 | EZH2 (0.56) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL8739274 | 0.75 | EZH2 (0.67) | MEN1KMT2AEZH2 | |
| SCHEMBL6120920 | 0.74 | MEN1 (0.77) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL8738112 | 0.74 | EZH2 (0.79) | MEN1KMT2AEZH2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |