Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | EZH2 | Q15910 | 8/20 | 0.59 |
| ▸ | UTS2R | Q9UKP6 | 6/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739662 | 0.94 | MEN1 (0.60) | MEN1KMT2AEZH2UTS2RGLA | |
| SCHEMBL8739702 | 0.89 | MEN1 (0.65) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL8739260 | 0.88 | MEN1 (0.58) | MEN1KMT2AEZH2UTS2RGLA | |
| SCHEMBL8738911 | 0.83 | MEN1 (0.59) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL8739274 | 0.82 | EZH2 (0.67) | MEN1KMT2AEZH2 | |
| SCHEMBL6119756 | 0.79 | EZH2 (0.77) | MEN1KMT2AEZH2 | |
| SCHEMBL8739365 | 0.77 | MEN1 (0.57) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL2215999 | 0.77 | UTS2R (0.50) | MEN1KMT2AUTS2RHTR1ACYP2D6 | |
| SCHEMBL6120920 | 0.77 | MEN1 (0.77) | MEN1KMT2AEZH2GLACYP2C9 | |
| SCHEMBL8738112 | 0.77 | EZH2 (0.79) | MEN1KMT2AEZH2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |