SCHEMBL8739460

SCHEMBL8739460

COCC1OC(n2cc(/C=C/C(=O)NCCN(CCNC(=O)C(F)(F)F)CCNC(=O)C(F)(F)F)c(=O)[nH]c2=O)CC1O

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TYMS P04818 3/20 0.53
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
TSHR P16473 1/20 0.47
TK1 P04183 1/20 0.47
BLM P54132 1/20 0.47
PMP22 Q01453 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
LMNA P02545 1/20 0.42
ALOX12 P18054 1/20 0.42
ADRA1A P35348 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16772882 0.92 TYMS (0.49) TYMSCYP1A2CYP3A4TSHRTK1
SCHEMBL13403287 0.91 TK1 (0.58) TYMSCYP1A2CYP3A4TSHRTK1
SCHEMBL13599906 0.89 TK1 (0.54) TYMSCYP1A2CYP3A4TSHRTK1
SCHEMBL887780 0.87 TK1 (0.56) TYMSCYP1A2CYP3A4TSHRTK1
SCHEMBL13403300 0.87 TK1 (0.56) TYMSCYP1A2CYP3A4TSHRTK1
SCHEMBL887784 0.87 TK1 (0.56) TYMSCYP1A2CYP3A4TSHRTK1
SCHEMBL887937 0.87 TK1 (0.53) TYMSCYP1A2CYP3A4TSHRTK1
SCHEMBL887563 0.86 TYMS (0.44) TYMSCYP1A2CYP3A4TSHRTK1
SCHEMBL24638622 0.86 TK1 (0.62) TYMSCYP1A2CYP3A4TSHRTK1
SCHEMBL14252429 0.86 TK1 (0.62) TYMSCYP1A2CYP3A4TSHRTK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2130835-B1 COMPOUND HAVING STRUCTURE DERIVED FROM MONONUCLEOSIDE OR MONONUCLEOTIDE, NUCLEIC ACID, LABELING SUBSTANCE, AND METHOD AND KIT FOR DETECTION OF NUCLEIC ACID RIKEN (JP) 2012-05-23 EP disclosed