Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 12/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.82 |
| ▸ | MAPT | P10636 | 12/20 | 0.82 |
| ▸ | GAA | P10253 | 10/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.82 |
| ▸ | PDE5A | O76074 | 1/20 | 0.76 |
| ▸ | PDE1A | P54750 | 1/20 | 0.76 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.76 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | USP2 | O75604 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739310 | 0.92 | MEN1 (0.78) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL8737946 | 0.91 | MEN1 (0.82) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL14132667 | 0.89 | MEN1 (0.78) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL14146498 | 0.89 | MEN1 (0.78) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL14132705 | 0.89 | MEN1 (0.78) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL8738396 | 0.86 | MEN1 (0.74) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL8737696 | 0.86 | MEN1 (0.75) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL8738009 | 0.86 | MEN1 (0.74) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL8739321 | 0.86 | MAPT (0.74) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL14133189 | 0.86 | MEN1 (1.00) | MEN1KMT2AMAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068209-A2 | BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-24 | — | — | WO | disclosed |