Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15487095 | 0.86 | CYP2A6 (0.54) | CYP2A6IMPDH2APPPOLBALDH1A1 | |
| SCHEMBL15487094 | 0.86 | CYP2A6 (0.54) | CYP2A6IMPDH2APPPOLBALDH1A1 | |
| SCHEMBL25001258 | 0.83 | APP (0.58) | CYP2A6IMPDH2APPPOLBALDH1A1 | |
| SCHEMBL16445879 | 0.82 | POLB (0.67) | CYP2A6IMPDH2APPPOLBALDH1A1 | |
| SCHEMBL30734352 | 0.82 | ALDH1A1 (0.57) | CYP2A6IMPDH2APPPOLBALDH1A1 | |
| SCHEMBL22950668 | 0.82 | ALDH1A1 (0.57) | CYP2A6IMPDH2APPPOLBALDH1A1 | |
| SCHEMBL30734350 | 0.82 | ALDH1A1 (0.57) | CYP2A6IMPDH2APPPOLBALDH1A1 | |
| SCHEMBL13811016 | 0.80 | APP (0.62) | CYP2A6IMPDH2APPPOLBALDH1A1 | |
| SCHEMBL7773883 | 0.79 | CYP2A6 (0.54) | CYP2A6IMPDH2APPPOLBALDH1A1 | |
| SCHEMBL2825118 | 0.78 | CYP2A6 (0.61) | CYP2A6IMPDH2APPPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012066549-A1 | DIPEPTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH AMYLOID FIBRIL FORMATION | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-05-24 | — | — | WO | disclosed |