Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162183 | 0.98 | ALDH1A1 (0.46) | ALDH1A1EPHX1LMNAMEN1TP53 | |
| SCHEMBL20162171 | 0.98 | ALDH1A1 (0.46) | ALDH1A1EPHX1LMNAMEN1TP53 | |
| SCHEMBL20162173 | 0.98 | ALDH1A1 (0.46) | ALDH1A1EPHX1LMNAMEN1TP53 | |
| SCHEMBL9176186 | 0.89 | TET2 (0.42) | LMNAMAPTCYP2D6CYP1A2TET2 | |
| SCHEMBL27880794 | 0.84 | EPHX1 (0.44) | ALDH1A1EPHX1LMNAMEN1TP53 | |
| SCHEMBL28468787 | 0.83 | ALDH1A1 (0.55) | ALDH1A1EPHX1LMNASMN1; SMN2EPHX2 | |
| SCHEMBL7364580 | 0.82 | ALDH1A1 (0.38) | ALDH1A1EPHX1LMNAMEN1TP53 | |
| SCHEMBL28572076 | 0.79 | ALDH1A1 (0.44) | ALDH1A1EPHX1LMNASMN1; SMN2EPHX2 | |
| SCHEMBL9294593 | 0.79 | ALDH1A1 (0.47) | ALDH1A1EPHX1LMNAMEN1KMT2A | |
| SCHEMBL1226217 | 0.79 | ALDH1A1 (0.44) | ALDH1A1EPHX1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639775-A | COGNITION ACTIVATORS | THE UNIVERSITY OF TOLEDO (US) | 1997-06-17 | — | — | US | disclosed |
| US-5486526-A | APPETITE SUPPRESSANTS | THE UNIVERSITY OF TOLEDO (US) | 1996-01-23 | — | — | US | disclosed |
| WO-1995011894-A1 | HISTAMINE H3-RECEPTOR ANTAGONISTS AND THERAPEUTIC USES THEREOF | THE UNIVERSITY OF TOLEDO (US) | 1995-05-04 | — | — | WO | disclosed |
| EP-0633882-A1 | 4- 4'-PIPERIDINYL OR 3'-PIRROLIDINYL] SUBSTITUTED IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS AND THERAPEUTIC USES THEREOF | THE UNIVERSITY OF TOLEDO (US) | 1995-01-18 | — | — | EP | disclosed |
| WO-1993020061-A1 | 4-[4'-PIPERIDINYL OR 3'-PIRROLIDINYL] SUBSTITUTED IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS AND THERAPEUTIC USES THEREOF | THE UNIVERSITY OF TOLEDO (US) | 1993-10-14 | — | — | WO | disclosed |