Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.51 |
| ▸ | PDE4A | P27815 | 11/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873742 | 0.97 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DS1PR5 | |
| Cyclopropanecarboxylic Acid Amide SCHEMBL873615 | 0.95 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL681826 | 0.93 | PDE4A (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2085994 | 0.93 | PDE4A (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL874670 | 0.92 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL683288 | 0.86 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL2140836 | 0.86 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL2142292 | 0.86 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL682664 | 0.86 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL2142298 | 0.86 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |