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Cyclopropanecarboxylic Acid Amide

Cyclopropanecarboxylic Acid Amide

SCHEMBL873615

COc1ccc(N2CCN(C)[C@@H](Cc3ccccc3)C2)cc1OC1CCCC1.NC(=O)C1CC1

nearest known ligand 0.48

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Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 15/20 0.48
▸ PDE4A P27815 9/20 0.45
▸ PDE4C Q08493 5/20 0.45
▸ PDE4D Q08499 5/20 0.45
▸ POLB P06746 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL874670 0.97 PDE4B (0.47) PDE4BPDE4APDE4CPDE4D
Cyclopropane Carboxylic Acid SCHEMBL874103 0.95 PDE4B (0.51) PDE4BPDE4APDE4CPDE4DPOLB
SCHEMBL681826 0.93 PDE4A (0.49) PDE4BPDE4APDE4CPDE4D
SCHEMBL2085994 0.93 PDE4A (0.49) PDE4BPDE4APDE4CPDE4D
SCHEMBL873742 0.92 PDE4B (0.48) PDE4BPDE4APDE4CPDE4D
SCHEMBL2140836 0.86 PDE4B (0.49) PDE4BPDE4APDE4CPDE4DPOLB
SCHEMBL683288 0.86 PDE4B (0.49) PDE4BPDE4APDE4CPDE4DPOLB
SCHEMBL2141419 0.86 PDE4B (0.50) PDE4BPDE4APDE4CPDE4D
SCHEMBL682651 0.86 PDE4B (0.50) PDE4BPDE4APDE4CPDE4D
SCHEMBL873257 0.85 PDE4B (0.51) PDE4BPDE4APDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2643000-A2 THERAPEUTIC PIPERAZINES Dart Neuroscience (Cayman) Ltd (KY) 2013-10-02 — — EP disclosed
WO-2012040258-A2 THERAPEUTIC PIPERAZINES HELICON THERAPEUTICS, INC. (US) 2012-03-29 — — WO disclosed