Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | MOK | Q9UQ07 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874686 | 0.85 | CYP3A4 (0.42) | CHRNA7DRD3DRD2CYP3A4CYP2D6 | |
| SCHEMBL874082 | 0.83 | MAPT (0.38) | CHRNA7DRD3DRD2CYP3A4CYP2D6 | |
| SCHEMBL874151 | 0.83 | CYP3A4 (0.40) | CHRNA7DRD3DRD2CYP3A4CYP2D6 | |
| SCHEMBL874570 | 0.82 | MOK (0.43) | CHRNA7DRD3DRD2MAPTKDM4E | |
| SCHEMBL874837 | 0.81 | KMT2A (0.37) | CHRNA7DRD3DRD2CYP3A4CYP2D6 | |
| SCHEMBL873657 | 0.81 | CYP3A4 (0.41) | CHRNA7DRD3DRD2CYP3A4CYP2D6 | |
| SCHEMBL875385 | 0.80 | MAPT (0.40) | CHRNA7CYP3A4CYP2D6CYP2C9KCNH2 | |
| SCHEMBL874025 | 0.79 | NAMPT (0.41) | CHRNA7DRD3DRD2CYP3A4CYP2D6 | |
| SCHEMBL874210 | 0.78 | MAPT (0.40) | CHRNA7NAMPTMAPTKDM4EHPGD | |
| SCHEMBL874515 | 0.77 | ATR (0.43) | CHRNA7DRD3DRD2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |