Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 13/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL619354 | 0.84 | PPARA (0.61) | KIF11PPARGPPARAPPARDADORA1 | |
| SCHEMBL21084961 | 0.84 | PPARA (0.61) | KIF11PPARGPPARAPPARDADORA1 | |
| SCHEMBL1530926 | 0.84 | PPARA (0.61) | KIF11PPARGPPARAPPARDADORA1 | |
| SCHEMBL28628939 | 0.83 | ADORA1 (0.51) | KIF11PPARGPPARAPPARDADORA1 | |
| SCHEMBL28628937 | 0.83 | ADORA1 (0.51) | KIF11PPARGPPARAPPARDADORA1 | |
| SCHEMBL906631 | 0.82 | CTSK (0.48) | KIF11PPARGPPARAPPARDADORA1 | |
| SCHEMBL5276867 | 0.82 | CTSK (0.48) | KIF11PPARGPPARAPPARDADORA1 | |
| SCHEMBL30753855 | 0.82 | PPARA (0.50) | KIF11PPARGPPARAPPARDADORA1 | |
| Methylene Chloride SCHEMBL27661057 | 0.81 | PPARA (0.58) | KIF11PPARGPPARAPPARDADORA1 | |
| SCHEMBL15764473 | 0.80 | ADORA1 (0.49) | KIF11PPARGPPARAPPARDADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784473-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1997-12-17 | — | — | EP | disclosed |
| EP-0784473-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996009820-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |