Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.55 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PLEC | Q15149 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076066 | 0.87 | MEN1 (0.50) | TPMTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL14107722 | 0.79 | TPMT (0.61) | TPMTHCAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL3398764 | 0.78 | ALDH1A1 (0.42) | GAAALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL3793129 | 0.78 | EGFR (0.40) | GAAALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL27620238 | 0.77 | KDM4E (0.53) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL8742132 | 0.77 | PPARA (0.57) | TPMTMEN1KMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL8956072 | 0.77 | HTR2B (0.42) | — | |
| Hydrochloric Acid SCHEMBL3396163 | 0.76 | ALDH1A1 (0.41) | GAAALDH1A1MAPTKDM4EHPGD | |
| Hydrochloric Acid SCHEMBL8742155 | 0.76 | ALDH1A1 (0.35) | GAAALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL28582621 | 0.75 | TPMT (0.55) | TPMTHCAR1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603650-B1 | 3,5-Substituted amino benzoylguanidines, process for their preparation, their use as medicine or diagnostic agent, as well as a medicine containing them | HOECHST AG (DE) | 1997-04-02 | — | — | EP | disclosed |
| US-5516805-A | 3,5-substituted aminobenzoylguanidines, their use as a medicament or diagnostic and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-14 | — | — | US | disclosed |
| EP-0603650-A1 | 3,5-Substituted amino benzoylguanidines, process for their preparation, their use as medicine or diagnostic agent, as well as a medicine containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-06-29 | — | — | EP | disclosed |