Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 6/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472360 | 0.95 | NPSR1 (0.38) | NPSR1GAAMAPTLMNAAVPR1B | |
| Trifluoroacetic Acid SCHEMBL8592809 | 0.92 | NPSR1 (0.36) | NPSR1TDP1GAACACNA1BUSP2 | |
| SCHEMBL7467560 | 0.89 | NPSR1 (0.38) | NPSR1GAAMAPTLMNAAVPR1B | |
| SCHEMBL7477246 | 0.87 | NPSR1 (0.39) | NPSR1GAAUSP2MAPTLMNA | |
| SCHEMBL7471274 | 0.86 | NPSR1 (0.38) | NPSR1GAAUSP2MAPTLMNA | |
| SCHEMBL7471625 | 0.85 | NPSR1 (0.41) | NPSR1GAAUSP2MAPTLMNA | |
| Trifluoroacetic Acid SCHEMBL8589290 | 0.85 | CACNA1B (0.36) | NPSR1TDP1GAACACNA1BUSP2 | |
| Trifluoroacetic Acid SCHEMBL8742824 | 0.85 | AVPR1A (0.41) | TDP1GAAMAPTAVPR1BMEN1 | |
| SCHEMBL7471149 | 0.84 | NPSR1 (0.39) | NPSR1GAAMAPTLMNAAVPR1B | |
| SCHEMBL8742735 | 0.84 | NPSR1 (0.40) | NPSR1GAAMAPTLMNAAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |