Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Reserpine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 known ✓ | Q05940 | 1/20 | 0.99 |
| ▸ | MEN1 | O00255 | 13/20 | 0.99 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.99 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.99 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.99 |
| ▸ | TSHR | P16473 | 6/20 | 0.99 |
| ▸ | HBB | P68871 | 5/20 | 0.99 |
| ▸ | MAPT | P10636 | 5/20 | 0.99 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.99 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.99 |
| ▸ | USP2 | O75604 | 4/20 | 0.99 |
| ▸ | CASP1 | P29466 | 4/20 | 0.99 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.99 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.99 |
| ▸ | CASP7 | P55210 | 3/20 | 0.99 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.99 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.99 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.99 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.99 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Reserpine SCHEMBL19639850 | 1.00 | MEN1 (0.99) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL14379427 | 0.99 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL15385127 | 0.99 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL1172973 | 0.99 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL4562878 | 0.99 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL8262666 | 0.99 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL5372164 | 0.99 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL12732449 | 0.99 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL22002247 | 0.99 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL20402680 | 0.99 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527026-B1 | Polyarylene sulfide resin composition less corrosive to metals | TOSOH CORP (JP) | 1997-01-08 | — | — | EP | claimed |