Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.74 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.74 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | NT5E | P21589 | 12/20 | 0.58 |
| ▸ | CD99 | P14209 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744111 | 1.00 | PDE2A (0.74) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| Clofarabine SCHEMBL5975001 | 0.85 | PDE2A (1.00) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| Clofarabine SCHEMBL12595105 | 0.85 | PDE2A (1.00) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| Clofarabine SCHEMBL17752021 | 0.85 | PDE2A (1.00) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| Clofarabine SCHEMBL9040 | 0.85 | PDE2A (1.00) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| Clofarabine SCHEMBL23620882 | 0.85 | PDE2A (1.00) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| Clofarabine SCHEMBL12139443 | 0.85 | PDE2A (1.00) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| Clofarabine SCHEMBL15468200 | 0.85 | PDE2A (1.00) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| Clofarabine SCHEMBL10026375 | 0.85 | PDE2A (1.00) | PDE2AADORA3ADORA2AADORA1ADRA1A | |
| Clofarabine SCHEMBL1467619 | 0.85 | PDE2A (1.00) | PDE2AADORA3ADORA2AADORA1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0473708-B1 | 2-HALO-9-(2-DEOXY-2-FLUORO-B-D-ARABINOFURANOSYL) ADENINE NUCLEOSIDE DERIVATIVES | SOUTHERN RES INST (US) | 1997-01-15 | — | — | EP | disclosed |