Known targets — ChEMBL curated mechanism
POLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PRIM1PRIM2RRM1RRM2RRM2B
The experimentally established mechanism targets of Clofarabine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 8/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 2/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 2/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | NT5E | P21589 | 8/20 | 0.69 |
| ▸ | CD99 | P14209 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | PNP | P00491 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clofarabine SCHEMBL12595105 | 1.00 | PDE2A (1.00) | PDE2AADORA3PDE4DPDE3AADORA2A | |
| Clofarabine SCHEMBL17752021 | 1.00 | PDE2A (1.00) | PDE2AADORA3PDE4DPDE3AADORA2A | |
| Clofarabine SCHEMBL1467619 | 1.00 | PDE2A (1.00) | PDE2AADORA3PDE4DPDE3AADORA2A | |
| Clofarabine SCHEMBL4570563 | 1.00 | PDE2A (1.00) | PDE2AADORA3PDE4DPDE3AADORA2A | |
| Clofarabine SCHEMBL5975001 | 1.00 | PDE2A (1.00) | PDE2AADORA3PDE4DPDE3AADORA2A | |
| Clofarabine SCHEMBL12139443 | 1.00 | PDE2A (1.00) | PDE2AADORA3PDE4DPDE3AADORA2A | |
| Clofarabine SCHEMBL23620882 | 1.00 | PDE2A (1.00) | PDE2AADORA3PDE4DPDE3AADORA2A | |
| Clofarabine SCHEMBL15468200 | 1.00 | PDE2A (1.00) | PDE2AADORA3PDE4DPDE3AADORA2A | |
| Clofarabine SCHEMBL9040 | 1.00 | PDE2A (1.00) | PDE2AADORA3PDE4DPDE3AADORA2A | |
| Clofarabine SCHEMBL10026375 | 1.00 | PDE2A (1.00) | PDE2AADORA3PDE4DPDE3AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10928405-B2 | Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells | ANALIZA, INC. (US) | 2021-02-23 | — | — | US | disclosed |
| US-20190178901-A1 | DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS | ANALIZA, INC. (US) | 2019-06-13 | — | — | US | disclosed |
| US-20150160246-A1 | DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS | ANALIZA, INC. (US) | 2015-06-11 | — | — | US | disclosed |
| US-20150160246-A1 | DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS | ANALIZA, INC. (US) | 2015-06-11 | — | — | US | disclosed |