SCHEMBL8744165

SCHEMBL8744165

CCCC(C(=O)F)C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 1/20 0.37
AKR1A1 P14550 1/20 0.37
CHRM3 P20309 1/20 0.37
HTR2A P28223 1/20 0.37
HTR2C P28335 1/20 0.37
ADRA1A P35348 1/20 0.37
HRH1 P35367 1/20 0.37
DRD3 P35462 1/20 0.37
SLC6A3 Q01959 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
CYP3A4 P08684 2/20 0.36
TSHR P16473 2/20 0.36
NFKB1 P19838 2/20 0.36
NPSR1 Q6W5P4 2/20 0.36
HDAC7 Q8WUI4 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
HDAC9 Q9UKV0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11736567 0.83 CHRM1 (0.39) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL28405230 0.83 MAPT (0.47) FAAHCES1CES2MEN1CYP1A2
SCHEMBL20543467 0.83 MAPT (0.47) FAAHCES1CES2MEN1CYP1A2
SCHEMBL20543471 0.83 MAPT (0.47) FAAHCES1CES2MEN1CYP1A2
SCHEMBL28403568 0.83 MAPT (0.47) FAAHCES1CES2MEN1CYP1A2
SCHEMBL826185 0.81 CHRM1 (0.48) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL2033952 0.80 TSHR (0.31) TSHR
SCHEMBL8743993 0.80 CYP2D6 (0.33) TSHRFAAH
SCHEMBL21295111 0.79 CA1 (0.39) CHRM1AKR1A1CHRM3HTR2AHTR2C
SCHEMBL28235034 0.78 HTT (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0753085-A1 PROCESS FOR PREPARING BRANCHED PERFLUOROCHEMICALS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-01-15 EP disclosed
WO-1995026429-A1 PROCESS FOR PREPARING BRANCHED PERFLUOROCHEMICALS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1995-10-05 WO disclosed