SCHEMBL8744272

SCHEMBL8744272

Clc1cccc(Oc2ccccc2)c1Br

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.58
ALDH1A1 P00352 2/20 0.46
NPSR1 Q6W5P4 1/20 0.46
LMNA P02545 2/20 0.45
POLB P06746 1/20 0.45
MAPT P10636 1/20 0.45
LTA4H P09960 1/20 0.42
TSHR P16473 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.41
GAA P10253 2/20 0.41
KMT2A Q03164 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
MAPK8 P45983 1/20 0.41
FABP3 P05413 1/20 0.40
FABP4 P15090 1/20 0.40
KDM1A O60341 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30542934 0.89 DPP4 (0.54) DPP4ALDH1A1NPSR1LMNAPOLB
SCHEMBL22159662 0.89 DPP4 (0.54) DPP4ALDH1A1NPSR1LMNAPOLB
SCHEMBL9780467 0.85 LTA4H (0.52) DPP4ALDH1A1LMNALTA4HTSHR
SCHEMBL3667279 0.83 DPP4 (0.61) DPP4ALDH1A1NPSR1LMNAPOLB
SCHEMBL31287795 0.83 MAPT (0.47) DPP4ALDH1A1POLBMAPTTSHR
SCHEMBL30542937 0.82 CYP1A2 (0.49) DPP4ALDH1A1MAPTLTA4HTSHR
SCHEMBL22159678 0.82 CYP1A2 (0.49) DPP4ALDH1A1MAPTLTA4HTSHR
SCHEMBL3790160 0.81 DPP4 (0.62) DPP4ALDH1A1NPSR1LMNAPOLB
SCHEMBL3789538 0.81 DPP4 (0.57) DPP4ALDH1A1NPSR1LMNAPOLB
SCHEMBL16891225 0.80 DPP4 (0.49) DPP4ALDH1A1NPSR1LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0427173-B1 Self-extinguishing polymeric compositions ENICHEM SPA (IT) 1997-01-15 EP claimed
US-5149735-A Organic halogen derivative, adduct of inorganic halide and zeolite, matrix modifier, thermoplastic polymer ENIMONT AUGUSTA INDUSTRIALE S.R.L. (IT) 1992-09-22 US claimed
EP-0427173-A2 Self-extinguishing polymeric compositions ENICHEM S.p.A. (IT) 1991-05-15 EP claimed
EP-0427173-B1 Self-extinguishing polymeric compositions ENICHEM SPA (IT) 1997-01-15 EP disclosed
US-5149735-A Organic halogen derivative, adduct of inorganic halide and zeolite, matrix modifier, thermoplastic polymer ENIMONT AUGUSTA INDUSTRIALE S.R.L. (IT) 1992-09-22 US disclosed
EP-0427173-A2 Self-extinguishing polymeric compositions ENICHEM S.p.A. (IT) 1991-05-15 EP disclosed