Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 7/20 | 0.47 |
| ▸ | GNAI3 | P08754 | 6/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.47 |
| ▸ | BCHE | P06276 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744379 | 0.85 | GNAO1 (0.50) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL8744422 | 0.84 | BCHE (0.50) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL8744405 | 0.83 | GNAO1 (0.48) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL8872700 | 0.80 | GNAO1 (0.54) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL8744456 | 0.79 | GNAO1 (0.57) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL8744403 | 0.77 | GNAO1 (0.50) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL8744343 | 0.76 | BCHE (0.50) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL8744425 | 0.75 | KCNH2 (0.53) | KCNH2CCR1CHRM3 | |
| SCHEMBL23553949 | 0.74 | HRH3 (0.47) | KCNH2 | |
| SCHEMBL8744453 | 0.74 | GNAO1 (0.46) | GNAO1GNAI3GNAI1BCHEKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614534-A | Derivatives of β, β-dimethyl-4-piperidineethanamine as inhibitors of the cholesterol biosynthesis | FOURNIER INDUSTRIE ET SANTE (FR) | 1997-03-25 | — | — | US | disclosed |
| EP-0699187-B1 | BETA,BETA-DIMETHYL-4-PIPERIDINEETHANAMINE DERIVATIVES AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER IND & SANTE (FR) | 1997-01-22 | — | — | EP | disclosed |
| EP-0699187-A1 | DERIVATIVES OF -g(b), -g(b)-DIMETHYL-4-PIPERIDINEETHANAMINE AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER IND & SANTE (FR) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994026713-A1 | DERIVATIVES OF β, β-DIMETHYL-4-PIPERIDINEETHANAMINE AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER INDUSTRIE ET SANTE (FR) | 1994-11-24 | — | — | WO | disclosed |