Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.89 |
| ▸ | CALCRL | Q16602 | 16/20 | 0.53 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-768673 SCHEMBL7207125 | 0.94 | KCNH2 (1.00) | KCNH2CALCRLRAMP1 | |
| SCHEMBL8745096 | 0.87 | KCNH2 (0.72) | KCNH2CALCRLRAMP1 | |
| SCHEMBL7965787 | 0.86 | KCNH2 (0.85) | KCNH2CALCRLRAMP1 | |
| SCHEMBL8462992 | 0.85 | KCNH2 (0.82) | KCNH2CALCRLRAMP1 | |
| SCHEMBL8745078 | 0.85 | KCNH2 (0.89) | KCNH2CALCRLRAMP1 | |
| SCHEMBL8620108 | 0.85 | KCNH2 (0.77) | KCNH2CALCRLRAMP1 | |
| SCHEMBL7744138 | 0.83 | KCNH2 (0.80) | KCNH2CALCRL | |
| SCHEMBL8745080 | 0.82 | KCNH2 (0.89) | KCNH2CALCRLRAMP1 | |
| SCHEMBL8462904 | 0.81 | KCNH2 (0.77) | KCNH2CALCRLRAMP1 | |
| SCHEMBL8820683 | 0.81 | KCNH2 (0.77) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776208-A4 | 2,3-DIHYDRO-1-(2,2,2-TRIFLUOROETHYL)-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINES | MERCK & CO INC (US) | 1997-12-29 | — | — | EP | disclosed |
| US-5658901-A | 2,3-dihydro-1-(2,2,2,-trifluoroethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepines | MERCK & CO., INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0776208-A1 | 2,3-DIHYDRO-1-(2,2,2-TRIFLUOROETHYL)-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINES | MERCK & CO. INC. (US) | 1997-06-04 | — | — | EP | disclosed |
| WO-1996005839-A1 | 2,3-DIHYDRO-1-(2,2,2-TRIFLUOROETHYL)-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINES | MERCK & CO., INC. (US) | 1996-02-29 | — | — | WO | disclosed |