Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.85 |
| ▸ | CCKBR | P32239 | 7/20 | 0.54 |
| ▸ | CCKAR | P32238 | 2/20 | 0.54 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.49 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.46 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.46 |
| ▸ | NOTCH3 | Q9UM47 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744138 | 0.92 | KCNH2 (0.80) | KCNH2CCKBRCCKARCALCRLHDAC3 | |
| L-768673 SCHEMBL7207125 | 0.92 | KCNH2 (1.00) | KCNH2CCKBRCCKARCALCRLRAMP1 | |
| SCHEMBL8820683 | 0.88 | KCNH2 (0.77) | KCNH2CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL8760273 | 0.88 | KCNH2 (0.75) | KCNH2CCKBRCCKARCALCRLRAMP1 | |
| SCHEMBL7744593 | 0.87 | KCNH2 (0.72) | KCNH2CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL7744135 | 0.87 | KCNH2 (0.72) | KCNH2CCKBRCCKARNOTCH1NOTCH3 | |
| SCHEMBL8745076 | 0.86 | KCNH2 (0.89) | KCNH2CALCRLRAMP1 | |
| SCHEMBL8462992 | 0.82 | KCNH2 (0.82) | KCNH2CALCRLRAMP1 | |
| L-768673 SCHEMBL8466533 | 0.82 | KCNH2 (0.74) | KCNH2CCKBRCCKARCALCRLRAMP1 | |
| SCHEMBL7743998 | 0.79 | KCNH2 (0.61) | KCNH2CCKBROXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214823-B1 | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. | 2001-04-10 | — | — | US | disclosed |