SCHEMBL8745109

SCHEMBL8745109

CC(=O)Nc1cccc2c(C(=O)O)cccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.54
CYP2C19 P33261 1/20 0.54
RXFP1 Q9HBX9 1/20 0.53
KMT2A Q03164 3/20 0.53
MEN1 O00255 2/20 0.53
GPR35 Q9HC97 1/20 0.49
CDC25B P30305 4/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
NR4A1 P22736 1/20 0.48
NR4A2 P43354 1/20 0.48
NR4A3 Q92570 1/20 0.48
KDM4E B2RXH2 2/20 0.47
ALDH1A1 P00352 2/20 0.47
HPGD P15428 2/20 0.47
MAPT P10636 1/20 0.47
HSD17B10 Q99714 1/20 0.47
MAPK1 P28482 1/20 0.45
CASP6 P55212 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1900214 0.87 RXFP1 (0.66) POLBCYP2C19RXFP1KMT2AMEN1
SCHEMBL8906402 0.83 KMT2A (0.48) POLBCYP2C19RXFP1KMT2AMEN1
SCHEMBL28076357 0.81 POLB (0.55) POLBCYP2C19KMT2AMEN1NPC1
SCHEMBL110042 0.81 POLB (0.72) POLBCYP2C19KMT2AMEN1NPC1
SCHEMBL27819891 0.81 POLB (0.72) POLBCYP2C19KMT2AMEN1NPC1
SCHEMBL29437050 0.81 POLB (0.72) POLBCYP2C19KMT2AMEN1NPC1
SCHEMBL9848863 0.80 NPC1 (0.62) POLBCYP2C19KMT2AMEN1NPC1
SCHEMBL11593694 0.80 POLB (0.56) POLBCYP2C19KMT2AMEN1NPC1
SCHEMBL30346643 0.80 POLB (0.56) POLBCYP2C19KMT2AMEN1NPC1
SCHEMBL4290828 0.80 KDM4E (0.59) POLBCYP2C19KMT2AMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0480705-B1 Monoazo lake pigment, process for producing the same and its use TOYO INK MFG CO (JP) 1997-01-29 EP disclosed
EP-0480705-A1 Monoazo lake pigment, process for producing the same and its use TOYO INK MANUFACTURING CO., LTD. (JP) 1992-04-15 EP disclosed