Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 6/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873395 | 0.96 | PDE4B (0.41) | PDE4BPDE11APDE10APDE4APDE4C | |
| SCHEMBL682935 | 0.96 | PDE4B (0.41) | PDE4BPDE11APDE10APDE4APDE4C | |
| SCHEMBL874749 | 0.93 | HTR1A (0.38) | — | |
| SCHEMBL682043 | 0.93 | HTR1A (0.38) | — | |
| SCHEMBL683081 | 0.91 | PDE4B (0.41) | PDE4BPDE11APDE10APDE4APDE4C | |
| SCHEMBL873715 | 0.91 | PDE4B (0.41) | PDE4BPDE11APDE10APDE4APDE4C | |
| SCHEMBL681981 | 0.90 | PDE4B (0.41) | PDE4BPDE11APDE10APDE4APDE4C | |
| SCHEMBL682661 | 0.90 | PDE4B (0.42) | PDE4BPDE11APDE10APDE4APDE4C | |
| SCHEMBL873271 | 0.90 | PDE4B (0.41) | PDE4BPDE11APDE10APDE4APDE4C | |
| SCHEMBL873766 | 0.90 | PDE4B (0.42) | PDE4BPDE11APDE10APDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | claimed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | claimed |