Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pindolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 7/20 | 0.75 |
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 0.75 |
| ▸ | HTR1A | P08908 | 11/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.75 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | HTR2C | P28335 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | DRD3 | P35462 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 2/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.75 |
| ▸ | HTR1B | P28222 | 2/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.75 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pindolol SCHEMBL5220 | 0.87 | HTR1A (1.00) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| Pindolol SCHEMBL29379249 | 0.87 | HTR1A (1.00) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| Pindolol SCHEMBL1157556 | 0.87 | HTR1A (1.00) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| Pindolol SCHEMBL29908300 | 0.87 | HTR1A (1.00) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| Pindolol SCHEMBL5219 | 0.87 | HTR1A (1.00) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| Pindolol SCHEMBL1157882 | 0.87 | HTR1A (1.00) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| Pindolol SCHEMBL2991558 | 0.85 | HTR1A (0.97) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| Pindolol SCHEMBL561162 | 0.85 | HTR1A (0.97) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| Propranolol SCHEMBL540824 | 0.83 | HTR1A (0.87) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| Pindolol SCHEMBL10494992 | 0.82 | HTR1A (0.91) | HTR1AADRB2ADRB1CYP1A2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750608-A1 | PHARMACEUTICAL PRODUCT COMPRISING A SALICYLATE OF AN ESTERIFIABLE BETA-BLOCKER | CAL INTERNATIONAL LIMITED (IE) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995020568-A1 | PHARMACEUTICAL PRODUCT COMPRISING A SALICYLATE OF AN ESTERIFIABLE BETA-BLOCKER | CAL INTERNATIONAL LIMITED (IE) | 1995-08-03 | — | — | WO | disclosed |