⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1477646 | 0.69 | — | — | |
| SCHEMBL538438 | 0.67 | — | — | |
| SCHEMBL31649405 | 0.67 | — | — | |
| SCHEMBL1856117 | 0.67 | — | — | |
| SCHEMBL122103 | 0.67 | — | — | |
| SCHEMBL3744044 | 0.67 | — | — | |
| Bromide SCHEMBL2745855 | 0.65 | — | — | |
| SCHEMBL31092010 | 0.65 | — | — | |
| SCHEMBL10898470 | 0.63 | — | — | |
| SCHEMBL7449478 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475676-B1 | Pregnane derivatives condensed in the 16,17 position with an N-substituted isoxazolidine ring as anti-inflammatory agents | CHIESI FARM SPA (IT) | 2020-05-27 | — | — | EP | disclosed |
| EP-2993178-A1 | GLUCOCORTICOID CONDENSED IN POSITION 16,17 WITH AN ISOXAZOLIDINE GROUP | CHIESI FARMACEUTICI S.p.A. (IT) | 2016-03-09 | — | — | EP | disclosed |
| US-20140148459-A1 | MATRIX METALLOPROTEINASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2014-05-29 | — | — | US | disclosed |
| US-8637662-B2 | Isoxazolidine derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-01-28 | — | — | US | disclosed |
| EP-2619185-A1 | MATRIX METALLOPROTEINASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2013-07-31 | — | — | EP | disclosed |
| EP-2475676-A2 | Pregnane derivatives condensed in the 16,17 position with an N-substituted isoxazolidine ring as anti-inflammatory agents | Chiesi Farmaceutici S.p.A. (IT) | 2012-07-18 | — | — | EP | disclosed |
| WO-2012038942-A1 | MATRIX METALLOPROTEINASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-03-29 | — | — | WO | disclosed |
| WO-2011029547-A2 | PREGNANE DERIVATIVES CONDENSED IN THE 16, 17 POSITION WITH AN N-SUBSTITUTED ISOXAZOLIDINE RING AS ANTI-INFLAMMATORY AGENTS | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-03-17 | — | — | WO | disclosed |
| US-20110065678-A1 | ISOXAZOLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-03-17 | — | — | US | disclosed |
| EP-0571031-A2 | Process for the preparation of savoury flavours | QUEST INTERNATIONAL B.V. (NL) | 1993-11-24 | — | — | EP | disclosed |
| US-4148995-A | FROM AN AZETIDINONE AND A FURANONE, MULTISTEP | Petrzilka, Theodor (CH) | 1979-04-10 | — | — | US | disclosed |