Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747262 | 0.83 | MAPT (0.45) | MAPK14MAPK10MAOALMNAMAPT | |
| SCHEMBL989662 | 0.82 | SLC6A2 (0.49) | LMNAMAPTNPSR1ALDH1A1 | |
| SCHEMBL8747316 | 0.82 | MAPK10 (0.45) | MAPK14MAPK10MAOALMNAMAPT | |
| SCHEMBL8747277 | 0.80 | NPY5R (0.43) | MAPK14MAOAMAPTSIGMAR1NPY5R | |
| SCHEMBL989046 | 0.78 | SLC6A2 (0.47) | MAOAMAPTMAOBALDH1A1 | |
| SCHEMBL8971786 | 0.77 | MAPK10 (0.48) | MAPK14MAPK10LMNAMAPTHTT | |
| SCHEMBL8747185 | 0.77 | KDM4E (0.48) | MAPK14MAPK10LMNAMAPTHTT | |
| SCHEMBL1862319 | 0.77 | KDM4E (0.36) | MAPK14MAPK10MAOAMAPTSIGMAR1 | |
| SCHEMBL7475657 | 0.76 | NPY5R (0.43) | MAPK14MAOAMAPTSIGMAR1NPY5R | |
| SCHEMBL12629538 | 0.74 | MAPT (0.41) | MAOALMNAMAPTSMN1; SMN2NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618900-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1997-03-12 | — | — | EP | disclosed |
| US-5519034-A | ANALGESICS | THE BOOTS COMPANY PLC (GB) | 1996-05-21 | — | — | US | disclosed |
| WO-1993013073-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |