SCHEMBL7475657

SCHEMBL7475657

COc1ccc2c(c1)C(C1(c3ccccn3)CCC1)=NCC2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 3/20 0.43
SIGMAR1 Q99720 1/20 0.39
MAOA P21397 2/20 0.39
EHMT2 Q96KQ7 1/20 0.37
MAOB P27338 1/20 0.37
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM5 P08912 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36
CYP19A1 P11511 4/20 0.36
CYP11B2 P19099 2/20 0.36
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
MPI P34949 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8747277 0.84 NPY5R (0.43) NPY5RSIGMAR1MAOAEHMT2MAOB
SCHEMBL1862319 0.83 KDM4E (0.36) NPY5RSIGMAR1MAOAEHMT2MAOB
SCHEMBL12629538 0.78 MAPT (0.41) NPY5RMAOAEHMT2MAOBMEN1
SCHEMBL8546617 0.78 MAOA (0.41) MAOAKDM4EALDH1A1MAPT
SCHEMBL989046 0.77 SLC6A2 (0.47) MAOAEHMT2MAOBMEN1KMT2A
SCHEMBL8747341 0.76 MAPK14 (0.40) NPY5RSIGMAR1MAOAMAOBALDH1A1
SCHEMBL7702378 0.72 NPY5R (0.54) NPY5RSIGMAR1MAOAMEN1NPC1
SCHEMBL989662 0.72 SLC6A2 (0.49) CYP19A1CYP11B2KDM4EALDH1A1MAPT
SCHEMBL7416672 0.71 MAOA (0.39) MAOAEHMT2CYP19A1CYP11B2KDM4E
SCHEMBL988268 0.70 PDK2 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5807868-A ANALGESICS; PSYCHOLOGICAL DISORDES; PARKINSON*S DIESASE;COGNITION ACTIVATORS; DRUG DEPENDENCE; DYSKINESIA KNOLL AKTIENGESELLSCHAFT (DE) 1998-09-15 US disclosed
US-5804586-A ANALGESICS, PSYCHOLOGICAL DISORDERS KNOLL AKTIENGESELLSCHAFT (DE) 1998-09-08 US disclosed
EP-0707570-B1 ISOQUINOLINE DERIVATIVES AS THERAPEUTIC AGENTS KNOLL AG (DE) 1998-05-06 EP disclosed
EP-0707570-A1 ISOQUINOLINE DERIVATIVES AS THERAPEUTIC AGENTS Knoll AG (DE) 1996-04-24 EP disclosed
WO-1995000489-A1 ISOQUINOLINE DERIVATIVES AS THERAPEUTIC AGENTS KNOLL AG (DE) 1995-01-05 WO disclosed