Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 10/20 | 0.44 |
| ▸ | DRD1 | P21728 | 10/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8747099 | 0.99 | MAOA (0.46) | MAOADRD2DRD1SLC6A9DRD4 | |
| SCHEMBL8747027 | 0.98 | MAOA (0.47) | MAOADRD2DRD1SLC6A9DRD4 | |
| SCHEMBL8747031 | 0.96 | MAOA (0.46) | MAOADRD2DRD1SLC6A9DRD4 | |
| SCHEMBL8747025 | 0.95 | MAOA (0.49) | MAOADRD2DRD1DRD4DRD3 | |
| SCHEMBL8747142 | 0.93 | DRD1 (0.53) | DRD2DRD1DRD4TSHRMAPK1 | |
| SCHEMBL8747307 | 0.91 | DRD1 (0.41) | MAOADRD2DRD1SLC6A9DRD4 | |
| SCHEMBL8747113 | 0.89 | MAOA (0.46) | MAOADRD2DRD1DRD4DRD3 | |
| SCHEMBL9300326 | 0.89 | MAOA (0.48) | MAOADRD2DRD1DRD4DRD3 | |
| SCHEMBL8747191 | 0.89 | DRD1 (0.56) | MAOADRD2DRD1TP53TSHR | |
| SCHEMBL8747006 | 0.89 | MAOA (0.50) | MAOADRD2DRD1DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618900-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1997-03-12 | — | — | EP | disclosed |
| US-5519034-A | ANALGESICS | THE BOOTS COMPANY PLC (GB) | 1996-05-21 | — | — | US | disclosed |
| EP-0618900-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS. | BOOTS CO PLC (GB) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993013073-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |