SCHEMBL8747411

SCHEMBL8747411

Clc1ccccc1C1CC1.O=C(Cl)Cl

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.53
RECQL P46063 1/20 0.53
OPRL1 P41146 4/20 0.49
SLC9A1 P19634 1/20 0.46
FFAR2 O15552 4/20 0.45
HCAR2 Q8TDS4 1/20 0.44
AKR1C3 P42330 1/20 0.44
AKR1C1 Q04828 1/20 0.44
TAS1R3 Q7RTX0 1/20 0.42
TAS1R1 Q7RTX1 1/20 0.42
TAS1R2 Q8TE23 1/20 0.42
ALDH1A1 P00352 1/20 0.42
LDHA P00338 1/20 0.42
LDHB P07195 1/20 0.42
HTR2A P28223 1/20 0.42
HTR2C P28335 1/20 0.42
HTR2B P41595 1/20 0.42
TRPV6 Q9H1D0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10978690 0.92 TP53 (0.50) TP53RECQLOPRL1SLC9A1FFAR2
Bicarbonate SCHEMBL10360630 0.92 TP53 (0.53) TP53RECQLOPRL1SLC9A1FFAR2
SCHEMBL1897406 0.89 TP53 (0.57) TP53RECQLOPRL1HTR2AHTR2C
Charcoal, Activated SCHEMBL5897477 0.87 TP53 (0.55) TP53RECQLOPRL1HTR2AHTR2C
Hydrochloric Acid SCHEMBL10978739 0.85 RAB9A (0.53) TP53RECQLOPRL1FFAR2HCAR2
SCHEMBL11832831 0.83 TP53 (0.48) TP53RECQLOPRL1FFAR2TRPV6
Cyanide SCHEMBL27463529 0.83 TP53 (0.52) TP53RECQLOPRL1HTR2AHTR2C
SCHEMBL3789653 0.80 TP53 (0.53) TP53RECQLOPRL1FFAR2HTR2A
SCHEMBL3784740 0.80 TP53 (0.53) TP53RECQLOPRL1FFAR2HTR2A
SCHEMBL9232062 0.80 TP53 (0.50) TP53RECQLOPRL1FFAR2HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0618900-B1 SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS KNOLL AG (DE) 1997-03-12 EP disclosed
US-5519034-A ANALGESICS THE BOOTS COMPANY PLC (GB) 1996-05-21 US disclosed
EP-0618900-A1 SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS. BOOTS CO PLC (GB) 1994-10-12 EP disclosed
WO-1993013073-A1 SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS THE BOOTS COMPANY PLC (GB) 1993-07-08 WO disclosed