Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 11/20 | 0.58 |
| ▸ | KCNJ11 | Q14654 | 11/20 | 0.58 |
| ▸ | ABCC8 | Q09428 | 6/20 | 0.58 |
| ▸ | KCNJ8 | Q15842 | 6/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633060 | 1.00 | ABCC9 (0.58) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL29516694 | 1.00 | ABCC9 (0.58) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL11168467 | 0.91 | ABCC9 (0.54) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL11152103 | 0.90 | ABCC9 (0.53) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL11153500 | 0.90 | ABCC9 (0.52) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL9463613 | 0.88 | ABCC9 (0.49) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL11173834 | 0.84 | ABCC9 (0.48) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL9351758 | 0.84 | ABCC9 (0.46) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL9351755 | 0.84 | ABCC9 (0.46) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL11162617 | 0.82 | ABCC9 (0.49) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618798-B1 | PYRIDYLGUANIDINE COMPOUNDS FOR TREATMENT OF ERECTILE DYSFUNCTION | UPJOHN CO (US) | 1997-03-12 | — | — | EP | claimed |
| EP-0618798-B1 | PYRIDYLGUANIDINE COMPOUNDS FOR TREATMENT OF ERECTILE DYSFUNCTION | UPJOHN CO (US) | 1997-03-12 | — | — | EP | disclosed |