Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNG | P07510 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CHRND | Q07001 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447883 | 0.82 | MEN1 (0.55) | HDAC4MEN1CYP2C9KMT2AHSD11B1 | |
| SCHEMBL615351 | 0.79 | OPRM1 (0.51) | HDAC4HCAR2MEN1CYP2C9KMT2A | |
| SCHEMBL11704952 | 0.78 | HDAC4 (0.44) | HDAC4HCAR2MEN1CYP2C9KMT2A | |
| SCHEMBL9729492 | 0.78 | MEN1 (0.60) | HDAC4HCAR2MEN1CYP2C9KMT2A | |
| SCHEMBL1561226 | 0.75 | HDAC4 (0.59) | HDAC4HCAR2MEN1CYP2C9KMT2A | |
| SCHEMBL3922847 | 0.74 | OPRL1 (0.47) | HDAC4MEN1CYP2C9KMT2ALMNA | |
| Ethylene SCHEMBL11093865 | 0.74 | HDAC4 (0.41) | HDAC4HCAR2MEN1CYP2C9KMT2A | |
| SCHEMBL13334110 | 0.73 | HDAC4 (0.58) | HDAC4HCAR2MEN1CYP2C9KMT2A | |
| SCHEMBL1561425 | 0.73 | HDAC4 (0.58) | HDAC4HCAR2MEN1CYP2C9KMT2A | |
| SCHEMBL27907597 | 0.73 | HDAC4 (0.67) | HDAC4HCAR2MEN1CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599732-B1 | Derivatives of 1-phenylbicyclo-2,2,2-octane, their preparation process and pharmaceutical compositions containing them | ADIR (FR) | 1997-03-12 | — | — | EP | disclosed |
| US-5403953-A | Antiarthritic and -inflammatory agents | ADIR ET COMPAGNIE (FR) | 1995-04-04 | — | — | US | disclosed |
| EP-0599732-A1 | Derivatives of 1-phenylbicyclo-2,2,2-octane, their preparation process and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-06-01 | — | — | EP | disclosed |