SCHEMBL8748019

SCHEMBL8748019

C=C(C)C(=O)OCCCN[SiH3]

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.56
THRB P10828 1/20 0.48
POLB P06746 1/20 0.43
APEX1 P27695 1/20 0.43
HTT P42858 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
ALDH1A1 P00352 3/20 0.41
ACHE P22303 6/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16309323 0.83 TSHR (0.55) TSHRTHRBPOLBAPEX1HTT
SCHEMBL1798323 0.82 TSHR (0.58) TSHRTHRBPOLBAPEX1HTT
SCHEMBL107954 0.82 TSHR (0.58) TSHRTHRBPOLBAPEX1HTT
SCHEMBL5144090 0.81 TSHR (0.79) TSHRTHRBPOLBAPEX1HTT
SCHEMBL25426 0.81 TSHR (0.79) TSHRTHRBPOLBAPEX1HTT
SCHEMBL182045 0.81 TSHR (0.72) TSHRTHRBPOLBAPEX1HTT
SCHEMBL2720435 0.81 TSHR (0.56) TSHRTHRBPOLBAPEX1HTT
SCHEMBL16309330 0.81 TSHR (0.56) TSHRTHRBPOLBAPEX1HTT
SCHEMBL16384923 0.81 TSHR (0.56) TSHRTHRBPOLBAPEX1HTT
Hydrochloric Acid SCHEMBL6053163 0.81 TSHR (0.56) TSHRTHRBPOLBAPEX1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-6228316-A None JP disclosed
EP-0539234-B1 Curable silicon composition THREE BOND CO LTD (JP) 1997-03-12 EP disclosed
US-5340847-A Liquid gaskets THREE BOND CO., LTD. (JP) 1994-08-23 US disclosed
JP-H06228316-A PRODUCTION OF SILICONE HAVING VINYL-POLYMERIZABLE GROUP AT ONE TERMINAL SHIN ETSU CHEM CO LTD 1994-08-16 JP disclosed
EP-0539234-A2 Curable silicon composition THREE BOND CO., LTD. (JP) 1993-04-28 EP disclosed