Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.78 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8748238 | 1.00 | LTB4R (0.78) | LTB4RLTB4R2MAPTGAARAB9A | |
| SCHEMBL8747956 | 1.00 | LTB4R (0.78) | LTB4RLTB4R2MAPTGAARAB9A | |
| SCHEMBL8747955 | 1.00 | LTB4R (0.78) | LTB4RLTB4R2MAPTGAARAB9A | |
| SCHEMBL8747965 | 0.99 | LTB4R (0.76) | LTB4RLTB4R2MAPTGAARAB9A | |
| SCHEMBL8747967 | 0.99 | LTB4R (0.76) | LTB4RLTB4R2MAPTGAARAB9A | |
| SCHEMBL8994891 | 0.90 | LTB4R (0.75) | LTB4RLTB4R2MAPTLMNAPRSS1 | |
| SCHEMBL8994930 | 0.90 | LTB4R (0.75) | LTB4RLTB4R2MAPTLMNAPRSS1 | |
| SCHEMBL8994928 | 0.89 | LTB4R (0.84) | LTB4RLTB4R2MAPTLMNAPRSS1 | |
| SCHEMBL8994880 | 0.89 | LTB4R (0.74) | LTB4RLTB4R2MAPTLMNAPRSS1 | |
| SCHEMBL8994893 | 0.89 | LTB4R (0.74) | LTB4RLTB4R2MAPTLMNAPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601977-B1 | Aromatic hydroxyamidine derivatives and their use as leukotriene B4 receptor antagonists | CIBA GEIGY AG (CH) | 1997-01-22 | — | — | EP | disclosed |
| US-5455274-A | Leukotriene antagonists; treating rheumatoid arthritis | CIBA-GEIGY CORPORATION (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0601977-A1 | Aromatic hydroxyamidine derivatives and their use as leukotriene B4 receptor anagonists | CIBA-GEIGY AG (CH) | 1994-06-15 | — | — | EP | disclosed |