Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.67 |
| ▸ | PDE4A | P27815 | 8/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | PDE5A | O76074 | 3/20 | 0.59 |
| ▸ | PDE1A | P54750 | 1/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415951 | 0.91 | POLB (0.64) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL7413887 | 0.91 | PDE5A (0.67) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL7423277 | 0.87 | PDE4D (0.78) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL8211635 | 0.86 | PDE5A (0.59) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL12189396 | 0.85 | KMT2A (0.69) | KMT2AMEN1HTT | |
| SCHEMBL4347187 | 0.85 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL7415380 | 0.84 | HTT (0.76) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL8197050 | 0.82 | PDE4D (0.82) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL8185285 | 0.81 | SMN1; SMN2 (0.74) | PDE4DPDE4BPDE4APDE4CPOLB | |
| SCHEMBL7340175 | 0.80 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607373-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-03-19 | — | — | EP | disclosed |
| US-5550137-A | Phenylaminocarbonyl derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-08-27 | — | — | US | disclosed |