⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14685976 | 0.72 | — | — | |
| SCHEMBL18919380 | 0.72 | CA1 (0.39) | — | |
| SCHEMBL2734238 | 0.71 | — | — | |
| SCHEMBL847661 | 0.71 | — | — | |
| SCHEMBL11791947 | 0.69 | LMNA (0.46) | — | |
| SCHEMBL27786735 | 0.69 | — | — | |
| SCHEMBL541873 | 0.67 | — | — | |
| SCHEMBL8666161 | 0.67 | — | — | |
| SCHEMBL701817 | 0.65 | TSHR (0.40) | — | |
| SCHEMBL29155217 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260124190-A1 | METHOD FOR TREATING A DISEASE OR CONDITION USING A PYRAZOLE COMPOUND OR FORMULATION THEREOF | RIGEL PHARMACEUTICALS, INC. (US) | 2026-05-07 | — | — | US | disclosed |
| US-12441723-B2 | Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations | RIGEL PHARMACEUTICALS, INC. (US) | 2025-10-14 | — | — | US | disclosed |
| US-12357623-B2 | Method for treating a disease or condition using a pyrazole compound or formulation thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2025-07-15 | — | — | US | disclosed |
| US-20240382470-A1 | Irak Inhibitor for Treating Cytokine Release-Related Conditions Associated With Infection by a Respiratory Virus | RIGEL PHARMACEUTICALS INC (US) | 2024-11-21 | — | — | US | disclosed |
| CN-118510771-A | IRAK inhibitors for the treatment of conditions associated with cytokine release associated with respiratory viral infection | 里格尔药品股份有限公司 | 2024-08-16 | — | — | CN | disclosed |
| EP-4399208-A1 | IRAK INHIBITOR FOR TREATING CYTOKINE RELEASE-RELATED CONDITIONS ASSOCIATED WITH INFECTION BY A RESPIRATORY VIRUS | Rigel Pharmaceuticals, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| US-20230399326-A1 | PYRAZOLE COMPOUNDS, FORMULATIONS THEREOF, AND A METHOD FOR USING THE COMPOUNDS AND/OR FORMULATIONS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | US | disclosed |
| WO-2023038815-A1 | IRAK INHIBITOR FOR TREATING CYTOKINE RELEASE-RELATED CONDITIONS ASSOCIATED WITH INFECTION BY A RESPIRATORY VIRUS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |
| US-20220306620-A1 | PYRAZOLE COMPOUNDS, FORMULATIONS THEREOF, AND A METHOD FOR USING THE COMPOUNDS AND/OR FORMULATIONS | RIGEL PHARMACEUTICALS, INC. (US) | 2022-09-29 | — | — | US | disclosed |
| US-11447449-B2 | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-09-20 | — | — | US | disclosed |
| EP-0577725-A4 | TARGETED DRUG DELIVERY VIA MIXED PHOSPHATE DERIVATIVES | UNIV FLORIDA (US) | 1996-04-17 | — | — | EP | disclosed |
| US-5413996-A | Delivery of steroid sex hormone or antiinflammatory steroid to the brain | UNIVERSITY OF FLORIDA (US) | 1995-05-09 | — | — | US | disclosed |
| US-RE34865-E | Antibiotics | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-02-21 | — | — | US | disclosed |
| EP-0577725-A1 | TARGETED DRUG DELIVERY VIA MIXED PHOSPHATE DERIVATIVES | UNIVERSITY OF FLORIDA (US) | 1994-01-12 | — | — | EP | disclosed |
| EP-0539493-A4 | TARGETED DRUG DELIVERY VIA PHOSPHONATE DERIVATIVES | — | 1993-06-02 | — | — | EP | disclosed |
| EP-0539493-A1 | TARGETED DRUG DELIVERY VIA PHOSPHONATE DERIVATIVES. | BODOR NICHOLAS S (US) | 1993-05-05 | — | — | EP | disclosed |
| US-5177064-A | TARGETED DRUG DELIVERY VIA PHOSPHONATE DERIVATIVES | UNIVERSITY OF FLORIDA (US) | 1993-01-05 | — | — | US | disclosed |
| WO-1992017185-A1 | TARGETED DRUG DELIVERY VIA MIXED PHOSPHATE DERIVATIVES | UNIVERSITY OF FLORIDA (US) | 1992-10-15 | — | — | WO | disclosed |
| US-5100887-A | Bactericides | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-03-31 | — | — | US | disclosed |
| WO-1992000988-A1 | TARGETED DRUG DELIVERY VIA PHOSPHONATE DERIVATIVES | BODOR NICHOLAS S (US) | 1992-01-23 | — | — | WO | disclosed |