Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 13/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12472560 | 0.93 | GPR139 (0.45) | GPR139SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL874951 | 0.90 | GPR139 (0.44) | GPR139SMN1; SMN2MMP1MMP2MMP3 | |
| SCHEMBL878139 | 0.89 | GPR139 (0.45) | GPR139SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL877877 | 0.86 | GPR139 (0.41) | GPR139SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL875089 | 0.85 | GPR139 (0.43) | GPR139SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL875322 | 0.85 | GPR139 (0.49) | GPR139SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL15733101 | 0.84 | GPR139 (0.41) | GPR139SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL15733404 | 0.83 | GPR139 (0.42) | GPR139SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL877148 | 0.81 | GPR139 (0.42) | GPR139SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL878249 | 0.81 | GPR139 (0.48) | GPR139SMN1; SMN2NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619185-A1 | MATRIX METALLOPROTEINASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038942-A1 | MATRIX METALLOPROTEINASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-03-29 | — | — | WO | disclosed |