SCHEMBL8752292

SCHEMBL8752292

Nc1ncnc2[nH]c(C3O[C@H](CO)[C@@H](O)[C@@H]3O)nc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 3/20 0.52
HSPA8 P11142 3/20 0.49
HSPA5 P11021 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.48
STAT6 P42226 2/20 0.48
KDM4E B2RXH2 1/20 0.48
GMNN O75496 1/20 0.48
LMNA P02545 1/20 0.48
MAPT P10636 1/20 0.48
BLM P54132 1/20 0.48
PMP22 Q01453 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
TSHR P16473 1/20 0.48
NFKB1 P19838 1/20 0.48
RXFP1 Q9HBX9 1/20 0.47
SLC28A2 O43868 2/20 0.47
GAPDH P04406 2/20 0.47
DPP4 P27487 1/20 0.47
MEN1 O00255 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4144251 1.00 HIF1A (0.52) HIF1AHSPA8HSPA5SMN1; SMN2STAT6
SCHEMBL4152180 1.00 HIF1A (0.52) HIF1AHSPA8HSPA5SMN1; SMN2STAT6
SCHEMBL11315629 0.84 HIF1A (0.48) HIF1AHSPA8HSPA5SMN1; SMN2STAT6
SCHEMBL3741584 0.83 HIF1A (0.46) HIF1ASMN1; SMN2STAT6KDM4EGMNN
SCHEMBL4080774 0.83 HIF1A (0.45) HIF1AHSPA8HSPA5SMN1; SMN2STAT6
SCHEMBL9346917 0.78 KDM4E (0.46) HIF1ASMN1; SMN2STAT6KDM4EGMNN
SCHEMBL9346538 0.78 KDM4E (0.46) HIF1ASMN1; SMN2STAT6KDM4EGMNN
SCHEMBL3664021 0.77 KDM4E (0.54) HIF1ASMN1; SMN2STAT6KDM4EGMNN
SCHEMBL9359905 0.77 KDM4E (0.54) HIF1ASMN1; SMN2STAT6KDM4EGMNN
SCHEMBL5474428 0.74 HIF1A (0.38) HIF1ASMN1; SMN2STAT6KDM4EGMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0759926-A1 PROCESS FOR PRODUCING ARABINO-NUCLEOSIDES SCHERING AKTIENGESELLSCHAFT (DE) 1997-03-05 EP disclosed
WO-1995032212-A1 PROCESS FOR PRODUCING ARABINO-NUCLEOSIDES SCHERING AKTIENGESELLSCHAFT (DE) 1995-11-30 WO disclosed