Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875550 | 0.87 | NAMPT (0.50) | NAMPTCHRM1HTR2AMCHR1MEN1 | |
| SCHEMBL882908 | 0.82 | NAMPT (0.46) | NAMPTCHRM1HTR2AMCHR1MEN1 | |
| SCHEMBL874266 | 0.81 | NAMPT (0.49) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL3055571 | 0.80 | NAMPT (0.49) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL882909 | 0.80 | NAMPT (0.49) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL3055626 | 0.80 | NAMPT (0.48) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL874907 | 0.79 | NAMPT (0.47) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL874264 | 0.79 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1 | |
| SCHEMBL3050002 | 0.79 | NAMPT (0.47) | NAMPTKITHDAC1CHRM1HTR2A | |
| SCHEMBL874755 | 0.79 | NAMPT (0.47) | NAMPTKITHDAC1CHRM1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |