Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 3/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875446 | 1.00 | ITGB1 (0.31) | ITGB1ITGA4PDK2ORAI1 | |
| SCHEMBL875448 | 1.00 | ITGB1 (0.31) | ITGB1ITGA4PDK2ORAI1 | |
| SCHEMBL10072315 | 0.95 | ITGB1 (0.31) | ITGB1ITGA4 | |
| SCHEMBL21863600 | 0.95 | ITGB1 (0.31) | ITGB1ITGA4 | |
| SCHEMBL876045 | 0.92 | PDK2 (0.33) | PDK2ORAI1 | |
| SCHEMBL876047 | 0.92 | PDK2 (0.33) | PDK2ORAI1 | |
| SCHEMBL876046 | 0.92 | PDK2 (0.33) | PDK2ORAI1 | |
| SCHEMBL875192 | 0.91 | — | — | |
| SCHEMBL875191 | 0.91 | — | — | |
| SCHEMBL875190 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619189-A1 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS | Zoetis LLC (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038851-A1 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS | PFIZER INC. (US) | 2012-03-29 | — | — | WO | disclosed |