Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8727305 | 0.74 | SLC6A4 (0.44) | SLC6A4TAAR1SLC6A2MAOASLC6A3 | |
| SCHEMBL8727296 | 0.74 | SLC6A4 (0.44) | SLC6A4TAAR1SLC6A2MAOASLC6A3 | |
| SCHEMBL10774940 | 0.72 | SLC6A4 (0.73) | SLC6A4TAAR1SLC6A2MAOASLC6A3 | |
| SCHEMBL27801609 | 0.70 | CARM1 (0.63) | SLC6A4CARM1PRMT6TAAR1SLC6A2 | |
| SCHEMBL29138035 | 0.69 | SLC6A4 (0.67) | SLC6A4TAAR1SLC6A2MAOASLC6A3 | |
| SCHEMBL27801597 | 0.69 | CARM1 (0.62) | SLC6A4CARM1PRMT6TAAR1SLC6A2 | |
| SCHEMBL8732240 | 0.68 | SLC6A4 (0.49) | SLC6A4TAAR1SLC6A2 | |
| SCHEMBL8636523 | 0.67 | SLC6A4 (0.51) | SLC6A4TAAR1SLC6A2SLC6A3 | |
| SCHEMBL28508358 | 0.65 | SLC6A4 (0.73) | SLC6A4TAAR1SLC6A2MAOASLC6A3 | |
| SCHEMBL27293364 | 0.65 | SLC6A4 (0.61) | SLC6A4TAAR1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772585-A1 | ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF | SMITHKLINE BEECHAM PLC (GB) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996004233-A1 | ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF | SMITHKLINE BEECHAM PLC (GB) | 1996-02-15 | — | — | WO | disclosed |