SCHEMBL8760075

SCHEMBL8760075

C=Cc1ccc(CC[Si](C)(C)C)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
TSHR P16473 1/20 0.36
HDAC8 Q9BY41 3/20 0.35
MAPT P10636 3/20 0.34
TP53 P04637 2/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
POLB P06746 1/20 0.33
CHRNB2 P17787 1/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA7 P36544 1/20 0.33
CHRNA4 P43681 1/20 0.33
TDP1 Q9NUW8 1/20 0.32
THRB P10828 3/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
ESR1 P03372 1/20 0.30
TAS1R3 Q7RTX0 1/20 0.30
TAS1R1 Q7RTX1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8759297 0.88 ALDH1A1 (0.42) ALDH1A1TSHRHDAC8MAPTTP53
SCHEMBL8760338 0.86 ALDH1A1 (0.41) ALDH1A1TSHRHDAC8MAPTTP53
SCHEMBL8760330 0.85 ALDH1A1 (0.39) ALDH1A1MAPTTP53MEN1KMT2A
SCHEMBL3182709 0.84 ALDH1A1 (0.42) ALDH1A1TSHRHDAC8MAPTTP53
SCHEMBL7975654 0.84 ALDH1A1 (0.42) ALDH1A1TSHRHDAC8MAPTTP53
SCHEMBL10622082 0.84 ALDH1A1 (0.42) ALDH1A1TSHRHDAC8MAPTTP53
SCHEMBL21846960 0.82 ALDH1A1 (0.41) ALDH1A1TSHRHDAC8MAPTTP53
SCHEMBL15952484 0.82 ESR1 (0.40) TDP1CA2ESR1CYP4F2CYP4A11
SCHEMBL1270510 0.81 ALDH1A1 (0.39) ALDH1A1TSHRHDAC8MAPTTP53
SCHEMBL31364537 0.80 ALDH1A1 (0.38) ALDH1A1TSHRHDAC8MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100093969-A1 Process for making siloxane polymers ZHANG RUZHI 2010-04-15 US disclosed
US-20070231671-A1 Catalyst Material For Use In Fuel Cell, Catalyst Membrane, Membrane Electrode Assembly and Fuel Cell FUJIFILM CORPORATION 2007-10-04 US disclosed
EP-0505997-B1 Process for producing styrenic polymer and copolymer IDEMITSU KOSAN CO (JP) 1997-05-28 EP disclosed
US-5378777-A Styrene monomer substituted with silicon group, transition metal complex catalyst IDEMITSU KOSAN CO., LTD. (JP) 1995-01-03 US disclosed
EP-0505997-A2 Process for producing styrenic polymer and copolymer IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-09-30 EP disclosed