SCHEMBL8760360

SCHEMBL8760360

Cc1c(C=C(Br)Br)cccc1COC1CCCCO1

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
KDM4C Q9H3R0 1/20 0.34
CREBBP Q92793 2/20 0.32
EP300 Q09472 1/20 0.32
PTPN1 P18031 1/20 0.32
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
TACR1 P25103 2/20 0.31
DHFR P00374 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8760443 0.88 MEN1 (0.34) MEN1KMT2AKDM4CCREBBPEP300
SCHEMBL9442671 0.84 KDM4C (0.36) MEN1KMT2AKDM4CCREBBPEP300
SCHEMBL8759396 0.84 MEN1 (0.36) MEN1KMT2AKDM4CCREBBPEP300
SCHEMBL8760063 0.84 MEN1 (0.34) MEN1KMT2AKDM4CCREBBPEP300
SCHEMBL8760072 0.80 KDM4C (0.38) MEN1KMT2AKDM4CCREBBPEP300
SCHEMBL11068192 0.78 KDM4C (0.38) MEN1KMT2AKDM4CCREBBPEP300
SCHEMBL9442675 0.77 HTR6 (0.40) MEN1KMT2AKDM4CCREBBPEP300
SCHEMBL18355699 0.76 TACR1 (0.46) MEN1KMT2AKDM4CCREBBPEP300
SCHEMBL8887331 0.76 KDM4C (0.41) MEN1KMT2AKDM4CCREBBPEP300
SCHEMBL8760058 0.75 KDM4C (0.36) MEN1KMT2AKDM4CCREBBPEP300

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0543238-B1 3-Isoxazolylphenyl-compounds, their preparation and application BASF AG (DE) 1997-06-04 EP disclosed
EP-0457204-B1 3-Isoxazolylbenzylesters, their preparation and utilization BASF AG (DE) 1994-12-07 EP disclosed
EP-0414059-B1 Dihalogenovinylbenzylesters, process and starting material for their preparation and their utilization for the control of parasites BASF AG (DE) 1993-10-27 EP disclosed
US-5256666-A Pesticides BASF AKTIENGESELLSCHAFT (DE) 1993-10-26 US disclosed
EP-0543238-A1 3-Isoxazolylphenyl-compounds, their preparation and application BASF Aktiengesellschaft (DE) 1993-05-26 EP disclosed
US-5151441-A Insecticides or miticides BASF AKTIENGESELLSCHAFT (DE) 1992-09-29 US disclosed
EP-0457204-A1 3-Isoxazolylbenzylesters, their preparation and utilization BASF Aktiengesellschaft (DE) 1991-11-21 EP disclosed
EP-0414059-A1 Dihalogenovinylbenzylesters, process and starting material for their preparation and their utilization for the control of parasites BASF Aktiengesellschaft (DE) 1991-02-27 EP disclosed