Sugi Predict

Sugi Predict / Compounds / SCHEMBL8760665

SCHEMBL8760665

SCHEMBL8760665

NS(=O)(=O)c1ccc(OCc2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 13/20 1.00
▸ CA9 Q16790 13/20 1.00
▸ CA1 P00915 12/20 1.00
▸ CA2 P00918 12/20 1.00
▸ CA7 P43166 9/20 1.00
▸ CA4 P22748 1/20 1.00
▸ CA5A P35218 1/20 1.00
▸ CA5B Q9Y2D0 1/20 1.00
▸ KDM4E B2RXH2 1/20 0.72
▸ MEN1 O00255 1/20 0.72
▸ ALDH1A1 P00352 1/20 0.72
▸ KMT2A Q03164 1/20 0.72
▸ PTGES2 Q9H7Z7 1/20 0.63
▸ MAOB P27338 2/20 0.59
▸ SOS1 Q07889 1/20 0.59
▸ GAA P10253 1/20 0.59
▸ MAPT P10636 1/20 0.59
▸ MAOA P21397 1/20 0.59
▸ RAB9A P51151 1/20 0.59
▸ SMN1; SMN2 Q16637 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7108878 0.85 CA12 (0.74) CA12CA9CA1CA2CA7
SCHEMBL9260073 0.84 CA12 (0.72) CA12CA9CA1CA2CA7
SCHEMBL28508086 0.84 CA12 (0.72) CA12CA9CA1CA2CA7
SCHEMBL14149692 0.83 CA12 (0.70) CA12CA9CA1CA2CA7
SCHEMBL20325533 0.83 CA12 (0.71) CA12CA9CA1CA2CA7
SCHEMBL22029377 0.83 CA12 (0.71) CA12CA9CA1CA2CA7
SCHEMBL22105993 0.83 CA1 (0.71) CA12CA9CA1CA2CA7
SCHEMBL22029372 0.83 CA2 (1.00) CA12CA9CA1CA2CA7
SCHEMBL926213 0.82 CA12 (0.70) CA12CA9CA1CA2CA7
SCHEMBL1462243 0.82 CA12 (0.70) CA12CA9CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12195472-B2 Substituted indole Mcl-1 inhibitors VANDERBILT UNIVERSITY (US) 2025-01-14 — — US disclosed
US-20240228463-A1 SODIUM CHANNEL INHIBITORS AND METHODS OF DESIGNING SAME GENENTECH, INC. (US) 2024-07-11 — — US disclosed
WO-2023028077-A1 SODIUM CHANNEL INHIBITORS AND METHODS OF DESIGNING SAME GENENTECH, INC. (US) 2023-03-02 — — WO disclosed
US-20230039309-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS VANDERBILT UNIVERSITY 2023-02-09 — — US disclosed
US-11208415-B2 Substituted indole Mcl-1 inhibitors VANDERBILT UNIVERSITY (US) 2021-12-28 — — US disclosed
US-10954193-B2 Substituted indole Mcl-1 inhibitors VANDERBILT UNIVERSITY (US) 2021-03-23 — — US disclosed
CN-106456602-B Substituted indole MCL-1 inhibitors 范德比尔特大学 2020-11-24 — — CN disclosed
EP-3122353-B1 SUBSTITUTED INDOLE MCL-1 INHIBITORS UNIV VANDERBILT (US) 2020-10-28 — — EP disclosed
EP-3038618-B1 SUBSTITUTED INDOLE MCL-1 INHIBITORS UNIV VANDERBILT (US) 2020-10-14 — — EP disclosed
US-20200140447-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS VANDERBILT UNIVERSITY 2020-05-07 — — US disclosed
EP-3038618-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS Vanderbilt University (US) 2016-07-06 — — EP disclosed
WO-2015148854-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS VANDERBILT UNIVERSITY (US) 2015-10-01 — — WO disclosed
WO-2015031608-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS VANDERBILT UNIVERSITY (US) 2015-03-05 — — WO disclosed
EP-0562824-B1 Thermal recording material FUJI PHOTO FILM CO LTD (JP) 1997-06-11 — — EP disclosed
EP-0510526-B1 Use of sulfonamides as drug and new sulfonamides HOFFMANN LA ROCHE (CH) 1996-12-04 — — EP disclosed
US-5464804-A Heat sensitive color layer with electron donor, colorless dye is black color aminofluoran, amino compound and isocyanate compound FUJI PHOTO FILM CO., LTD. (JP) 1995-11-07 — — US disclosed
US-5288688-A Comprising electron-donating colorless dye, isocyanate and amino compounds; antifogging, discoloration inhibition, storage stability FUJI PHOTO FILM CO., LTD. (JP) 1994-02-22 — — US disclosed
US-5270313-A Treatment of circulatory disorders HOFFMANN-LA ROCHE INC. (US) 1993-12-14 — — US disclosed
EP-0562824-A2 Thermal recording material FUJI PHOTO FILM CO., LTD. (JP) 1993-09-29 — — EP disclosed
EP-0510526-A1 Use of sulfonamides as drug and new sulfonamides F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) 1992-10-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200140447-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS MCL1, BCL2L1, BCL3 CA12 4753/4885CA9 4823/4885CA1 4568/4885
US-20240228463-A1 SODIUM CHANNEL INHIBITORS AND METHODS OF DESIGNING SAME CACNA1I, CACNA1B, CACNA1C CA12 1502/4885CA9 503/4885CA1 442/4885
US-20230039309-A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS MCL1, BCL2L1, BCL3 CA12 4753/4885CA9 4823/4885CA1 4568/4885
US-10954193-B2 Substituted indole Mcl-1 inhibitors MCL1, BCL2, BCL2L1 CA12 4458/4885CA9 4624/4885CA1 3557/4885
US-12195472-B2 Substituted indole Mcl-1 inhibitors MCL1, BCL2L1, BCL3 CA12 4753/4885CA9 4823/4885CA1 4568/4885
US-11208415-B2 Substituted indole Mcl-1 inhibitors MCL1, BCL2L1, BCL3 CA12 4753/4885CA9 4823/4885CA1 4568/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.