Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153740 | 0.81 | PKM (0.62) | PKMTHRBSIRT6LMNAPOLB | |
| SCHEMBL8761254 | 0.77 | MAOB (0.61) | PKMSIRT6LMNAPOLBTP53 | |
| Hydrochloric Acid SCHEMBL27788112 | 0.76 | PKM (0.52) | PKMTHRBSIRT6LMNAPOLB | |
| SCHEMBL18184512 | 0.76 | PKM (0.55) | PKMTHRBSIRT6LMNAPOLB | |
| SCHEMBL21379454 | 0.75 | HTR2C (0.60) | PKMLMNATP53HTR2CMEN1 | |
| SCHEMBL2587301 | 0.75 | PKM (1.00) | PKMSIRT6LMNAPOLBPKLR | |
| SCHEMBL8761290 | 0.74 | PRKCI (0.55) | PKMTHRBSIRT6LMNAPKLR | |
| SCHEMBL4617771 | 0.74 | PKM (0.54) | PKMTHRBSIRT6LMNAPOLB | |
| SCHEMBL516947 | 0.74 | PKM (0.54) | PKMTHRBSIRT6LMNAPOLB | |
| SCHEMBL15792810 | 0.74 | PKM (0.46) | PKMTHRBLMNAPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0614887-B1 | Indole-sulfonamides as antitumor agents | LILLY CO ELI (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1994020101-A1 | ANTITUMOR COMPOSITIONS AND METHODS OF TREATMENT | ELI LILLY AND COMPANY (US) | 1994-09-15 | — | — | WO | disclosed |
| EP-0614887-A1 | Indole-sulfonamides as antitumor agents | ELI LILLY AND COMPANY (US) | 1994-09-14 | — | — | EP | disclosed |