Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | BLM | P54132 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633477 | 0.84 | MEN1 (0.79) | MEN1KMT2AHTTBLMNPC1 | |
| SCHEMBL18070361 | 0.83 | MEN1 (0.68) | MEN1KMT2AHTTBLMNPC1 | |
| SCHEMBL14848654 | 0.83 | MEN1 (0.68) | MEN1KMT2AHTTBLMNPC1 | |
| SCHEMBL14984262 | 0.80 | MEN1 (0.67) | MEN1KMT2AHTTBLMNPC1 | |
| SCHEMBL8421913 | 0.74 | MEN1 (0.48) | MEN1KMT2AHTTBLMNPC1 | |
| SCHEMBL18070601 | 0.73 | PRMT1 (0.70) | MEN1KMT2AHTTBLMNPC1 | |
| Iodide SCHEMBL7546369 | 0.73 | APP (0.66) | MEN1KMT2AHTTBLMNPC1 | |
| SCHEMBL14984251 | 0.72 | KMT2A (0.63) | MEN1KMT2AHTTBLMNPC1 | |
| SCHEMBL10399515 | 0.72 | MEN1 (0.60) | MEN1KMT2AHTTBLMNPC1 | |
| SCHEMBL7620078 | 0.72 | MAPT (0.50) | MEN1KMT2AHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545380-B1 | Silver halide emulsions spectrally sensitized to infrared radiation with novel cyanine dyes | POLAROID CORP (US) | 1997-04-23 | — | — | EP | disclosed |
| US-5254455-A | Silver halide emulsions spectrally sensitized to infrared radiation with novel cyanine dyes | POLAROID CORPORATION (US) | 1993-10-19 | — | — | US | disclosed |
| EP-0545380-A1 | Silver halide emulsions spectrally sensitized to infrared radiation with novel cyanine dyes | POLAROID CORPORATION (US) | 1993-06-09 | — | — | EP | disclosed |